As former President Donald Trump appeared to be slipping into the White House against a weakened President Joe Biden, the Republican Party was also optimistic about the likely outcomes of this year’s House and Senate elections. Trump would become president, and his supporters would undoubtedly carry a few senators and representatives across the finish line, giving Republicans a workable majority in government.

But that was before the Democratic Party dumped Biden in favor of Vice President Kamala Harris. Where Trump had a comfortable 3-point lead over Biden, Harris now leads by 2 points. Larger leads in swing states like Arizona and Georgia have also disappeared. Republicans must confront the real possibility that Trump could lose in November, and the real threat Harris would pose if Democrats were to take the House and retain 50 seats in the Senate.

In the House of Representatives, Republicans hold a slim eight-seat majority in a chamber of 435. Election forecasters have said Republicans have a strong chance of winning 209 of this year’s races, compared with 205 seats for the Democrats. That leaves 21 seats up for grabs between now and Election Day. Democrats need to win just 13 to regain the majority, a distinct possibility. All 21 toss-up races are worth spending money on, but the biggest fights are in blue states, with Reps. Ken Calvert (R-CA) and David Valadao (R-CA) facing tough reelections in California, and Rep. Mike Lawler (R-NY) facing a close fight in New York.

The Senate map is slightly more favorable to Republicans, but they will still need to defeat an incumbent to take control from the Democrats. Sen. Jon Tester (D-MT), who has been in office since 2007, is the Republicans’ best chance to take a seat from the Democrats. Navy SEAL officer Tim Sheehy has a 5-point lead over Tester. Republicans also have a chance to win in Ohio, where Sen. Sherrod Brown (D-OH) is ahead of Republican businessman Bernie Moreno; Michigan, where Rep. Elissa Slotkin (D-MI) is defeating former Rep. Mike Rogers, a Republican; and Pennsylvania, where Sen. Bob Casey (D-PA) is defeating Republican businessman David McCormick.

What makes Harris so dangerous if the Democrats take the House and keep the Senate is that she and the Senate Democrats have promised to end the filibuster. All this talk of “gridlock” if Harris wins is wishful thinking at best.

Democrats talk about the importance of political “norms,” but they have a long history of tossing aside norms when it suits them. That’s what happened when then-Senate Majority Leader Harry Reid, a Democrat, ended the judicial filibuster in 2013, and it will happen again if Democrats retain the Senate under a Harris administration.

Trillions of dollars in Green New Deal spending, mandatory gun buybacks, a ban on gas-powered car purchases and amnesty for millions of illegal immigrants could all pass the Senate without a single Republican vote if Harris becomes president.

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Some have argued that the Supreme Court could stop Harris’s power grab, but Democrats have a plan for that, too: expanding the court. They’ve written legislation that would force Republican-appointed Supreme Court justices to retire early by stripping them of jurisdiction to hear the most important cases.

The danger of a Harris administration combined with a Democratic House and Senate is immeasurable but enormous. The first line of defense is to deny her the White House. But Republicans should also do everything they can to defeat Democrats at the ballot box.